The University created the School of Sciences in the year 2006 to establish a unique educational programs of study different from human-centred subjects (Arts and Social Sciences) considering the importance of Science Education in development of nation in many areas. However, the Science discipline is considered as a basic human motivator that enables technological advances in improving the living standards of impoverished millions. The components of Science include the discovering of new concepts by conducting experiments, facilitating practical observations, deriving hypothesis and making interpretations to establish a theory from knowledge sources. The main objective of the Science Programs is to turn natural curiosity of humans in creation of new knowledge that make studying science as attractive as learning to find solutions to the problems in addressing the needs of the society. Ultimately the Society is 'driven' by ideas and products from science and the influence of science continue to increase in all realms of human life.

The School is currently having five Departments: Mathematics, Physics, Chemistry, Botany, and Zoology. The School also comprises of Polytechnics located at Hyderabad, Bengaluru, Darbhanga, Kadapa and Cuttack. Three Industrial Training Institutes (ITI) located at Hyderabad, Bengaluru, Darbhanga also established under the School to promote vocation trade based skills. The School offers Bridge Course for Madarsa students; and B.Sc. program in three streams viz., B.Sc. (Physical Science - MPC), B.Sc. (Physical Science - MPCS) and B.Sc. (Life Science). Following are the details of eligibility for the B.Sc. programs: